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For instance, in M1 pro-inflammatory macrophages (Ms), there is a metabolic break at isocitrate dehydrogenase in the TCA cycle due to suppression of its mRNA expression, leading to the accumulation of citrate and itaconate, which drive lipid synthesis and stabilization of anti-inflammatory transcription factors, such as nuclear factor-erythroid factor 2-related factor 2 (NRF2) and activating transcription factor 3 (15)

A more promising approach involved boosting the expression and activity of GLO I, a catalyst in MG metabolism

Overall, PSC is a progressive disease that will lead to cirrhosis and associated complications

Available from: Johannsen P, Ostergaard K, Christensen JE, Worm M, Rasmussen K

Consistency and Quality Control : Using allogenic sources allows for stringent quality control and consistency in the stem cell products, ensuring high efficacy and safety across treatments [36-39]